abstract：BACKGROUND:Several clinical studies have evaluated the diagnostic efficiency of fecal elastase 1 (FE1) determination using monoclonal antibodies (ScheBo-Tech, Wettenberg, Germany). We report the results of the comparison of this method with a polyclonal based assay (BioServ AG, Rostock, Germany). METHODS:We collected ...

journal_title：Clinical laboratory

authors： Miendje Y,Maisin D,Sipewa MJ,Deprez P,Buts JP,De Nayer P,Philippe M

更新日期：2004-01-01 00:00:00

abstract：:There has been a long debate since the introduction of blood analysis prior to major sports events, to find out whether blood samples should be analysed right away on the site of competition or whether they should be transported and analysed in an anti-doping laboratory. Therefore, it was necessary to measure blood sa...

journal_title：Clinical laboratory

authors： Robinson N,Mangin P,Saugy M

更新日期：2004-01-01 00:00:00

abstract：:Fondaparinux is a synthetic selective inhibitor of factor Xa recently approved for thromboprophylaxis after major orthopedic surgery. Determination of its concentration gives valuable insight into specific pharmacokinetics or safety studies. The aim of the study was to develop direct, sensitive, precise and accurate a...

journal_title：Clinical laboratory

authors： Paolucci F,Frasa H,Van Aarle F,Capdevla A,Clavies MC,van Dinther T,Donat F,Hendriks Y,van den Heuvel M,Nadal T,Lagrange F,Necciari J,Perez Y

更新日期：2003-01-01 00:00:00

abstract：:The value of Toxoplasma gondii-specific antibodies for the diagnosis of reactivated toxoplasmosis in immunocompromised patients is controversely discussed. The present study was performed to investigate the value of testing for antibodies against Toxoplasma gondii in patients undergoing bone marrow transplantation (BM...

journal_title：Clinical laboratory

authors： Janitschke K,Held T,Krüiger D,Schwerdtfeger R,Schlier G,Liesenfeld O

更新日期：2003-01-01 00:00:00

abstract：:Four stand-alone analyzers in a centralized laboratory were replaced by two modular analytical systems processing 45 methods of the general chemistry and specific protein segment. This consolidation led to a reduction of the daily workflow and operational costs. The cost saving with 1.3 million reported results per ye...

journal_title：Clinical laboratory

authors： Stolz H,Dossler B,Keller F,Steigerwald U

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:Measurement of autoantibodies against thyroperoxidase (TPOAb) plays an important role in the diagnosis of autoimmune thyroid disease. The assessment of reference intervals for TPOAb, however, is a controversial issue since elevated TPOAb values are sometimes found in subjects without other evidence of thyroid...

journal_title：Clinical laboratory

authors： Zöphel K,Saller B,Wunderlich G,Grüning T,Koch R,Wilde J,Mann K,Franke WG

更新日期：2003-01-01 00:00:00

abstract：:C-reactive protein as the most important acute phase reactant in clinical use provides information about acute as well as chronic inflammatory processes. This application requires an improvement of traditional assays that have been available to the clinical laboratory regarding lipemic interference, precision especial...

journal_title：Clinical laboratory

authors： Hafner G,Larkin T,Peetz D,Erbes H,Eyres H,Wrynn K,Lackner KJ

更新日期：2002-01-01 00:00:00

abstract：:Primary aldosteronism is a potentially curable form of hypertension. Recent studies using the plasma aldosterone to plasma renin activity ratio as screening test in hypertensive populations have demonstrated a high prevalence of primary aldosteronism close to 10%. This frequency is clearly higher than the classically ...

journal_title：Clinical laboratory

authors： Fardella CE,Mosso L

更新日期：2002-01-01 00:00:00

abstract：:Variability of bone marker measurements is a major problem in their clinical application. Most studies on marker variability have been performed in healthy subjects and over relatively short intervals of time. We prospectively evaluated the long-term variability of bone markers in 102 postmenopausal women diagnosed wi...

journal_title：Clinical laboratory

authors： Seibel MJ,Koeller M,Van der Velden B,Diel I

更新日期：2002-01-01 00:00:00

abstract：:An assay is described for the determination of interleukin 8 (IL-8) in whole blood lysate instead of plasma or serum. EDTA-anticoagulated umbilical cord blood or capillary blood was added to a detergent-containing lysing reagent. This sample was used directly for determination of IL-8 using the Immulite IL-8 assay kit...

journal_title：Clinical laboratory

authors： Kohse KP,Carl A,Steinbach G

更新日期：2002-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) is prevalent in 50-80% of the population worldwide. After primary infection it remains in a latent state until reactivation. Stressful events induce the release of corticosteroids which activate HCMV. The effect of examination stress on HCMV reactivation among first year female students wa...

journal_title：Clinical laboratory

authors： Sarid O,Anson O,Yaari A,Margalith M

更新日期：2002-01-01 00:00:00

abstract：:B-type natriuretic peptide, a proteohormone secreted by the left ventricle in response to wall-tension, is a promising laboratory parameter for the detection and follow-up of heart failure. In this report analytical validation data of a non-isotopic point-of-care testing system for the quantitative determination of BN...

journal_title：Clinical laboratory

authors： Vogeser M,Jacob K

更新日期：2001-01-01 00:00:00

abstract：:Peat and different peat preparations are successfully used in clinical therapies for different indications (as, for instance, in the field of gynecology). New studies show the biochemical effects of peat components which they have aside from their physical-thermal effects. This is of extraordinary interest with regard...

journal_title：Clinical laboratory

authors： Beer AM,Fey S,Walch S,Lüthgens K,Ostermann T,Lukanov J

更新日期：2001-01-01 00:00:00

abstract：:Immunofluorescence tests have been the gold standard in Epstein-Barr virus (EBV) serology during the past decades. Despite their high quality they cannot resolve significant problems with i) anticellular reactivity of some sera, ii) missing anti-EBNA-1 response in 5% of healthy individuals, and iii) loss of anti-EBNA-...

journal_title：Clinical laboratory

authors： Bauer G

更新日期：2001-01-01 00:00:00

abstract：:Evidence-based medicine (EBM) is a method for solving problems concerning the assessment of laboratory testing in patient care. Practising EBM involves the use of the available evidence to make health care decisions. The best way to practice EBM is the development, validation and implementation of guidelines. Guidelin...

journal_title：Clinical laboratory

authors： Thomas L,Thomas C

更新日期：2001-01-01 00:00:00

abstract：:Apolipoprotein B-100 (apo B-100) plays an essential role in lipoprotein metabolism where it is involved in the clearance of LDL particles from the bloodstream. The mutation Arg3500Gln in the apo B-100 gene impairs the binding of the LDL particles to the LDL receptor, resulting in elevated LDL-cholesterol levels in the...

journal_title：Clinical laboratory

authors： Klingler KR,Zech D,Wielckens K

更新日期：2000-01-01 00:00:00

abstract：:A sensitive immunoluminometric assay originally designed to measure C-reactive protein (CRP) in neonates and minimal serum volumes was adapted to measure this protein in a routine method without prior sample dilution. The concentration range covered without prior dilution was 10 micrograms/l to 20 mg/l using a sample ...

journal_title：Clinical laboratory

authors： Wood WG,Lüdemann J,Mitusch R,Heinrich J,Maass R,Frick U

更新日期：2000-01-01 00:00:00

abstract：:Rickettsial diseases (typhus and spotted fever group rickettsioses, scrub typhus and Q fever) may pose a serious public health problem, namely when they are non-diagnosed or misdiagnosed. Although rickettsiae can be isolated from or detected in clinical specimens, serological tests still remain an indispensable tool i...

journal_title：Clinical laboratory

authors： Kovácová E,Kazár J

更新日期：2000-01-01 00:00:00

abstract：:"Soluble liver antigen" (SLA) has been reported to be an infrequent but in certain cases a unique marker of autoimmune hepatitis, with cytokeratins 8 and 18 as major antigenic components. Using precharacterized sera, we could confirm trypsin sensitivity and a molecular weight of approximately 50 kD of the reactive pro...

journal_title：Clinical laboratory

authors： Martin L,Bäurle A,Fiehn W,Volkmann M

更新日期：2000-01-01 00:00:00

abstract：:About one in eight to ten women living in Western countries will develop breast cancer during her lifetime and between 5-10% of these cases result from an inherited susceptibility to the disease. Within the past few years, a number of genes associated with a high risk of breast cancer have been identified, including B...

journal_title：Clinical laboratory

authors： Hamann U

更新日期：2000-01-01 00:00:00